《2013 ESMO臨床實(shí)踐指南:成人急性髓性白血病的診斷、治療與隨訪(fǎng)》 內(nèi)容預(yù)覽
Acute myeloblastic leukaemias in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
制定者:歐洲腫瘤內(nèi)科學(xué)會(huì)(ESMO,European Society for Medical Oncology)
出處: Ann Oncol. 2013 Aug 22.
該指南為歐洲腫瘤內(nèi)科學(xué)會(huì)2013年版的成人急性髓性白血病診斷、治療與隨訪(fǎng)指南,指南介紹了成人急性髓性白血病的病因與流行病學(xué)、診斷與分子生物學(xué)、風(fēng)險(xiǎn)評(píng)估與診斷因素、治療、個(gè)體化醫(yī)療以及療效評(píng)估與預(yù)后。
指南推薦要點(diǎn):
Diagnostic work-up of AML must in include morphology of pe**heral blood and bone marrow, cytogenetics and molecular genetics assessed before start of therapy
HLA-typing of patient and family members to plan for allogeneic stem cell transplantation where indicated
AML should only be treated in specialised and experienced centres offering a multidisciplinary approach, and the possibility of clinical trials
AML therapy with curative intent includes induction chemotherapy (incorporating an anthracycline and cytarabine), consolidation which in intermediate to high-risk patients may incorporate allogeneic stem cell transplantation
APL needs a specific therapy approach. ATRA must be started whenever in a case of leukaemia the differential diagnosis of APL is considered, and combined with anthracycline-based chemotherapy once the diagnosis of APL is confirmed
ESMO急性髓性白血病診治隨訪(fǎng)指南:
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